Prospective survey of beta-lactamases produced by ceftazidime- resistant Pseudomonas aeruginosa isolated in a French hospital in 2000.

نویسندگان

  • Christophe De Champs
  • Laurent Poirel
  • Richard Bonnet
  • Danielle Sirot
  • Catherine Chanal
  • Jacques Sirot
  • Patrice Nordmann
چکیده

In 2000, at the Université d'Auvergne teaching hospital in Clermont-Ferrand, France, 44 (6.2%) strains of Pseudomonas aeruginosa were found to be resistant to ceftazidime. After genotyping, 34 strains were selected. Nine had an additional beta-lactamase: OXA-21 (n = 6), PSE-1 (CARB-2) (n = 2), or PER-1 (n = 1). Ceftazidime resistance was related solely to the overproduction of the cephalosporinase in 30 strains. Sequencing of five bla(AmpC) genes encoding cephalosporinases with different pIs showed 99% identity with the ampC gene of P. aeruginosa PAO1.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 46 9  شماره 

صفحات  -

تاریخ انتشار 2002